desktop_.ini is a malicious configuration file filled with essential settings that are required for monitoring main parasite components. There are several viruses that create and use this file. They are W32.Fujacks.E worm and Fujacks.e. So, if you found desktop_.ini in your system, you should check your PC with reputable anti-spyware.
desktop_.ini is mostly used to initialize a parasite on startup, describe its standard behavior and reconfigure its base functions. This file doesn't carry any payload, so it is not capable of violating people's privacy or initiating serious harm on computer. However, it helps for the virus to work properly, so you should definitely remove desktop_.ini from your computer. For that we recommend using RegCure Pro.
Note that sometimes desktop_.ini may actually be a legitimate part of your operating system! No matter that such cases are rare, you should always examine files before their elimination. For that you can use a previously mentioned program.