Microsoft.VC80.MFC.manifest is a malicious file, which is installed and used by ErrorSweeper. When involved to malicious activity, this file is mostly used for monitoring system's performance and degrading it. However, another part of PC experts have declared that this file can be set to display annoying pop-up ads, cause browser's redirects, block certain programs and initiate similar issues on the system.
NOTE! In some of the cases, a presence of Microsoft.VC80.MFC.manifest does not mean that your system is infected. The file may actually belong to a fully legitimate application and therefore must stay intact. If you are in doubt, please scan the Microsoft.VC80.MFC.manifest file using RegCure Pro. This will help you to avoid computer-related issues.