igfxpers.exe is a legitimate non-system process, which runs automatically when computer starts. This file is usually installed as a part of Intel Graphics Media Accelerator Driver and is responsible for additional configuration options for Nvidia graphics solutions. igfxpers.exe should be running on your machine if you have a notebook because it switches your screen resolutions when using a docking station or external monitor. However, it consumes much system resources, so if you don't find igfxpers.exe important, you can safely terminate it.
Malware creators use the names of legitimate files in order to tick users and hide their viruses. If your igfxpers.exe is located NOT in the C:\Windows\System32 folder, you should check your computer with anti-spyware and make sure that it's safe.